Aer Lingus

Aer Lingus is the national airline of Ireland. It is headquartered at Dublin Airport, Ireland. †¢The airline operates 43 aircraft and carries on average 10 million passengers per annum. †¢The airlines primary mission is to connect Ireland with the world and the world to Ireland by offering its customers the best product in the Irish airline market at a competitive price. The airline’s primary markets are Ireland, the United Kingdom, Europe and the United States. The Irish people typically undertake several overseas flights a year. This is partly driven by Ireland’s status as an island nation but also reflects the inherent propensity among the Irish to travel to visit overseas destinations. tgp2012 1 Marketing orientation Marketing orientation In 2001 after the 9/11 effect on the airline industry Aer Lingus introduces their first model of low fares to compete with other low fare In 2001 after the 9/11 effect on the airline industry Aer Lingus introduces their first model of low fares to compete with other low fare airlines. The airline was close to bankruptcy and they had to find new waysairlines. how to keep the company afloat. They carried out numerous to see The airline was close tosurveys within the industry to find new what was needed/wantedtheorder to prosper. They carried out numerous bankruptcy and they had to identify ways to see how to keep in company afloat. So after the initial surveys they lowered their fares and altered/removed/added new destinations. Since prosper. ompany’s marketing surveys within the industry to identify what was needed/wanted in order to then the So after the initial surveys they loweredupdated/upgraded many times putting the customer in theSince then the company’s marketing orientation has been their fares and altered/removed/added new destinations. driving seat. orientation has been updated/upgraded many times putting the customer in the driving seat. Marketing mix Marketing mix

Beta thalassaemia major Essay Example | Topics and Well Written Essays - 1500 words

Beta thalassaemia major - Essay Example This classification is based on the type of globin chain (alpha or beta) which is affected. This clearly indicates that hemoglobin structure is central to the pathology of thalassaemia. Beta thalassaemia or Cooley's anemia as it is called refers to decreased beta chain production and hence deficits in hemoglobin due to defects in the gene forming the chain Hemoglobin (Hb) is protein responsible for oxygen carrying in the body. It is made of four peptide chains, two alpha or a chains and two beta or b chains. Hemoglobin synthesis is controlled by genes which are switched on and off at different phases in the human life (beginning at the embryonic stage). Gamma genes regulate formation of fetal hemoglobin, which is switched to beta genes postnatally. It is about the 9th gestational week that the transcription switch from g chain to b chain production starts. Normally fetal hemoglobin synthesis declines gradually during this time but continues until 9 months of age. It is at about the 9th month after birth that the switch is completed.(Sarnaik 2005). This beta gene therein controls beta chain production in adults. In patients suffering from beta thalassaemia, there is a switch from a normal gamma-globin gene, in the fetus to an abnormal beta-globin gene, in the adult. (Blau 1994). ... tations have been described so far) Beta-thalassaemia major is hence a result of transmission of the mutated form of beta-globin gene from both parents, to the offspring. This results in inheritance of both defected form of the gene and has severe clinical manifestations for the patient. Clinical features and abnormalities As has been described above, beta thalassemia major refers to a decreased production of beta globin chains which are required for formation of normal haemoglobin in the blood. This results in decreased levels of normal haemoglobin(A) in the body. Interestingly there are evidences of increased levels of fetal (F) and abnormal haemoglobin (A2). Recent studies established that this abnormal increase in other Hb forms was due to production of excess of alpha chains, some of which are consequently utilized to synthesize hemoglobins which do not require beta chains, such as hemoglobin F (a2 g2) or hemoglobin A2 (a2 d2) and hence the elevated levels of such hemoglobins! (Perrimond 2001). Clinically this is very relevant as it leads to excessively reduced RBC life, this is primarily due to precipitation of free alpha chains on the RBCs. Other clinical features are is extremely severe hypochromic anemia as a result of ineffective erythropoesis. There is also significant decrease in hemoglobin content per cell and microcytosis. In order to compensate for this the body attempts to increase the red cellproduction. This results in increase marrow cavities and 'extramedullary erythropoeisis' in the liver and spleen. The consequences of such endeavours may result in hepatosplenomegaly, bone defects and much discomfort (pain) in patients. In children, there is high incidence of growth deficit, cardiac problems and jaundice (due to excessive break down of red

Risk Management and Policy Decision-Making Essay - 1

Risk Management and Policy Decision-Making - Essay Example the fear of the resiliency of the breaks in the weather condition and even the managers of the manufacturers of the machine, Ferrari, refused but the persuasion by the officials ensured that the cars were launched according to the plans and previous schedules of launching. The decision to launch the first Ferrari was arrived at after numerous hours of debating which involved both the management of the rallying event, the makers and all the external political forces. All this were influenced by numerous bureaucracies in the handling of the actual decision of whether to proceed with the launch or not to proceed. Since the decisions were being made from a multifaceted approach, the heroic engineers tried to avoid the accident by cancelling the launch but the administrators due to their lack of the actual knowledge and evidence that could lead to disastrous outcome of the launch; they went ahead and initiated it. However there is the actual lack of evidence that portrays previous accidents correlating the slippery road surface and the rainy weather as having disastrous effects on the brakes of the super road machines. There is clearly a missing evidence of previous accidents in relation to the brakes resiliency due to variation in the rain drizzles. However the indication of the failure of the car breaks is explained as indicated by the Ferraris explanation using their chats does not show the evidence of similar accidents or disasters with a cause that is due to the correlation with drizzles variability and the physical conditions of the roads post the rainy event. Even though some of the previous launches under similar conditions indicated the possibility of the failure of breaks , but there was no evidence of cause in relation to the crushing of Ferrari one. This accident had an impact in the future management of the high speed rally cars launches in relation to the weather of the day. In relation to the management approaches and the ideologies of the engineers,